The age‐specific reference intervals for tPSA tPSA , fPSA fPSA , and %fPSA in healthy Han ethnic male

摘要

Introduction Prostate cancer ( PC ) is one of the most common malignancies in male, and has become the fastest growing malignancy in recent years. Prostate specific antigen ( PSA ) is widely used as a tumor marker to screen for PC . Many studies have been performed to define the reference intervals ( RI s) for total circulating PSA ( tPSA ). The results were different among different nations and races, even in the same race. Few researches have been performed on the RI s of free PSA ( fPSA ) and the ratio of free to total PSA (% fPSA ). In this study, we aimed to simultaneously determine the age‐specific RI s for tPSA , fPSA , and % fPSA in the healthy Han ethnic male. Methods A total of 1862 apparently healthy male aged from 21 to 94?years were included in our study. Nonparametric 95th percentile intervals were used to define the RI s. Results The reference limits in different age groups (21–50, 51–60, 61–70, 71–80, and ≥81?years) were 2.07, 3.59, 4.93, 6.83, and 7.73?ng/mL for tPSA , and 0.60, 0.76, 0.83, 1.30, and 2.41?ng/mL for fPSA . The RI s of % fPSA were ≥0.16 for 21–50?years and ≥0.13 for male over 50?years old. Conclusions We established age‐specific RI s for tPSA , fPSA and % fPSA . The newly established RI s should be more suitable for Chinese Han ethnic male. It will be valuable for physicians to make exact medical decision and appropriate medical intervention.