Potential of Gold Nanoparticles as Antioxidants in Diabetic Mice

摘要

The study investigated the antioxidative and antihyperglycemic ability of gold nanoparticles in diabetic mice. Sol-gel method was applied for the synthesis of gold nanoparticles (AuNPs). The formed nanoparticles were characterized using transmission electron microscopy (TEM) and dynamic light scattering (DLS) investigation. Parallel to this, male mice (n = 20),were used to assess the antidiabetic potential of the AuNPs for a period of 15 days. Blood glucose, serum creatinine, ALT, AST, ALP levels were the endpoints evaluated at the end of the experimental period. The levels of antioxidant enzymes, superoxide dismutase (SOD), Glutathione peroxidase (Gpx), Catalase (CAT) and levels of reduced glutathione (GSH) were also assessed. A histolopathological analysis of the liver and kidney was performed to assess the tissue damage. The results of Zetasizer and Transmission and Scanning Electron Microscopy images showed the presence of spherical nanoparticles with an average size of 10 nm. The treatment with AuNPs on diabetic mice did not show any adverse effect. The alterations in the haematological parameters, antioxidant system and the hitopathological alterstions in liver and kidney induced in the diabetic mice were significantly reversed on treatment with AuNPs. The key findings of the study show a promising potential of gold nanoparticles in nanomedicine in diabetes management.