Aspheric versus wavefront-guided aspheric photorefractive keratectomy in eyes with significant astigmatism

摘要

Purpose To compare the refractive and higher-order aberrations (HOAs) outcomes after photorefractive keratectomy (PRK) in patients with significant astigmatism using aspheric versus wavefront-guided aspheric profiles. Setting Ophthalmic Research Center and Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Negah Eye Hospital, Tehran, Iran. Design Prospective randomized case series. Methods One eye of each patient with a refractive astigmatism more than 2.00 diopters (D) randomly received aspheric PRK. In the?other eye, wavefront-guided and aspheric treatment was performed using a personalized treatment advanced algorithm. Visual acuity, refractive errors, and HOAs were compared between the 2 groups preoperatively and 12?months postoperatively. Results The study comprised 32 patients (64 eyes). The mean preoperative refractive astigmatism was ?4.07 D ± 1.64 (SD) and ?4.02?±?1.55 D in the aspheric group and wavefront-guided aspheric group, respectively ( P ?=?.2). The mean postoperative astigmatism was ?0.46?±?0.37 D and ?0.82?±?0.53 D in the?aspheric group and wavefront-guided aspheric group, respectively ( P ?=?.02). Postoperatively, the root mean square of total HOAs was significantly increased in both groups. However, compared with wavefront-guided aspheric PRK, aspheric PRK induced fewer HOAs ( P ?=?.003). Conclusions In eyes with high astigmatism, post-PRK residual astigmatism was lower in the aspheric group than in the wavefront-guided aspheric group. The increase in HOAs was significantly higher in the wavefront-guided aspheric group than in the aspheric group.