Reversible black tongue: A little known side effect of imipenem/cilastatin and evidence for novel mode of action

摘要

Abstract What is known and objective Black tongue syndrome (BT) is a rare and self‐limiting disorder which can result from physiological and metabolic condition and ingestion of toxic substances. Medications are the most common cause of BT. Case summary A 39‐year‐old male patient presented with BT after the initiation of imipenem/cilastatin. Within one week of cessation of these drugs, the patient's tongue returned to a normal colour. What is new and conclusion This is the first case of BT induced by imipenem/cilastatin. Withdrawal of the combination is likely to reverse the condition.