The 'immunologic advantage' of HIV-exposed seronegative individuals.

摘要

I would like to commend Dr Masaaki Miyazawa and his colleagues on the excellent comprehensive review article on HIV-seronegative individuals who have been exposed to HIV (ESN) [1]. However, I would like to point out some omissions in their article.The authors assert 'HIV-specific CD4+ T-cell responses were initially described in heavily infected men enrolled from the MACS cohort' and cite two publications from 1991 and 1992. They neglect to report in the article that these men were identified from a study done by Imagawa and colleagues in the MACS 2 years earlier that described a group of 31 heavily exposed HIV-seronegative men from whom HIV was isolated and who were PCR-positive for HIV [2].