Crystal Quality Control by Using the Millimeter-Size Tube Type Taylor Vortex Continuous Crystallizer

摘要

Introduction of a continuous production system to the pharmaceutical field has become realistic. In this field, many kinds of organic crystals with high anisotropic aspect are produced. Hence, crystal morphology affects the pharmaceutical productivity. Therefore, a high production method with crystal morphology improvement currently attracts attention by using a continuous crystallizer. In order to improve the production rate, it is necessary to enhance the crystal growth rate by increasing the mass transfer. The stirring method using Taylor Vortex has been developed in the crystallization research field. The objectives of this study are to design a double-cylinder shaped milli-size crystallizer in order to realize Taylor Vortex, and to evaluate the productivity and crystal morphology. As a result, it was clear that the proposed crystallizer had a productivity about 40 times greater than a conventional batch crystallizer and had a performance which improved the aspect ratio by 59%.