Pulmonary and Systemic Vascular Resistances After Cardiopulmonary Bypass: Role of Hemolysis

摘要

Objectives: Prolonged cardiopulmonary bypass (CPB) is associated with hemolysis, resulting in increased plasma oxyhemoglobin and vascular nitric oxide depletion. The authors hypothesized that hemolysis associated with CPB would reduce nitric oxide bioavailability, resulting in high pulmonary and systemic vascular resistances that after CPB would normalize gradually over time, due to clearance of plasma oxyhemoglobin. The authors also investigated whether prolonged CPB (>= 140 min) produced increased levels of hemolysis and greater pulmonary and systemic vasoconstriction.