Change of Amyloid-beta 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus

摘要

Background: Alzheimer's disease (AD) pathology in idiopathic normal pressure hydrocephalus (iNPH) contributes to poor shunt responses. Amyloid-beta 1-42 (A beta(42)) toxic conformer was recently identified with features of rapid oligomerization, strong neurotoxicity and synaptotoxicity.