Vascular Scaffold for Guides Endothelial Cell Alignment by Electrohydrodynamic and Electrospinning

摘要

Tissue engineering vascular scaffolds have become a popular research and a cutting-edge study. The endothelialization of vascular scaffold has been one of the problems that need to be solved in tissue engineering vascular scaffold. The researchers tried to solve this problem by selecting more suitable materials, by modifying the surface of the material, and so on. In this paper, the electrospinning film with aligned fibers is prepared by electrospinning and electrohydrodynamic, and a double-layer vascular scaffold with a biomimetic structure is formed by manually crimping the films. Experimental results of cell seeding demonstrate that parallel fibers can guide human umbilical vein endothelial cells growth, and the cell activity reached more than 81%. It is also beneficial for the endothelialization process of vascular scaffolds. This article provides a new idea for the study of vascular scaffold fabrication.