The effect of molecular weight of biodegrad able hydrogel components on indomethacin relese from dextran and poly(DL) lactic acid based hydrogels

摘要

Biodegradable hybrid hydrogels from chemically mofified dextran and poly(DL) lactic acid (PDLIA) were prepared by UV photocrosslinking of different molecular weights (MWs)of these precursors.A series biodegradable hybrid hydrogels were obtained by changing the composition ratio of hydrogels and MWs of dextran and PDLLA.These hydrogels were characterized by swelling and invitro biodegradation-induced morphological structure changes.Indomethacin(IDM) was entrapped in these hydrogels and the release kinetics were investigated ina pH 7.4 phosphate buffer solution.The relationship between hydrogel swelling and biodegradation,IDM release fromthe netwrok hydrogels and the molecular weights of dextran and PDLLA were studied.It was found that the swelling and biodegradation of these hybrid hydrogels were afected by both the MWs of the polymer component and the composition ratio of the hydrogels.IDM release from the hybrid hydrogel network hydrogels and the molecular weights of dextran and PDLLA were studied.It was found that the swelling and biodegradation of these hybrid hydrogels were affected by both the MWs of the polymer component and the composition ratio of the hydrogels.IDM release from the hybrid hydrogel structure and hydrophobicity of the hydrogels;the MW effect on IDM release profiles was smaller than on hydrogel properties.