Disease-only alleles at the extreme ends of the human ZMYM3 exceptionally long 5 ' UTR short tandem repeat in bipolar disorder: A pilot study

摘要

Objective: The X-linked ZMYM3 gene (also known as ZNF261) contains the longest STR, (GA) 32, identified in a human protein-coding gene 5'UTR (ENST00000373998.5: ZMYM3-207). This STR reaches maximum length in human, and is located in a complex string of four consecutive GA-STRs with a human-specific formula across the complex. A previous study in Iranian male schizophrenia (SCZ) patients revealed co-occurrence of the extreme short and long alleles of the STR with SCZ. Here we studied the allelic distribution of this STR in bipolar disorder (BD) type I. The interval encompassing the human ZMYM3 STR complex was PCR-amplified and sequenced in 546 male subjects, consisting of 157 BD patients and 389 controls.