Task-positive and task-negative networks in major depressive disorder: A combined fMRI and EEG study

摘要

Background: The study of intrinsic connectivity networks, i.e., sets of brain regions that show a high degree of interconnectedness even in the absence of a task, showed that major depressive disorder (MDD) patients demonstrate an increased connectivity within the default mode network (DMN), which is active in a resting state and is implicated in self-referential processing, and a decreased connectivity in task-positive networks (TPNs), which increase their activity in attention tasks. Cortical localization of this 'dominance' of the DMN over the TPN in MDD patients is not fully understood. Besides, this effect has been investigated using fMRI and its electro-physiological underpinning is not known.