Postoperative Antibacterial Prophylaxis for the Prevention of Infectious Complications Associated With Tube Thoracostomy in Patients Undergoing Elective General Thoracic Surgery A Double-blind, Placebo-Controlled, Randomized Trial

摘要

Objective: To determine whether extended postoperative antibacterial prophylaxis for patients undergoing elective thoracic surgery with tube thoracostomy reduces the risk of infectious complications compared with preop-erative prophylaxis only.Design: Prospective, randomized, double-blind, placebo-controlled trial.Setting: Brigham and Women's Hospital, an 800-bed tertiary care teaching hospital in Boston, Massachusetts.Participants: A total of 251 adult patients undergoing elective thoracic surgery requiring tube thoracostomy between April 2008 and April 2011.Interventions: Patients received preoperative antibacterial prophylaxis with cefazolin sodium (or other drug if the patient was allergic to cefazolin). Postoperatively, patients were randomly assigned (at a 1:1 ratio) using a computer-generated randomization sequence to receive extended antibacterial prophylaxis (n= 125) or placebo (n= 126) for 48 hours or until all thoracostomy tubes were removed, whichever came first.