HIGHLY EFFICIENT CONSTRUCTION OF CF3-CONTAINING 3,3 '-PYRROLIDINYL-DISPIROOXINDOLES VIA BASE-CATALYZED DIASTEREOSELECTIVE [3+2] ANNULATION

摘要

An efficient base-catalyzed diastereoselective [3+2] cyclization of isatin-derived azomethine ylides with methyleneindolinones was developed. The process enables efficient incorporation of CF3 groups into highly functionalized 3,3'-pyrrolidinyl-dispirooxindoles bearing four contiguous chiral centers, including two adjacent spiro quaternary stereocenters, with high yields and diastereoselectivities.