SYNTHESIS OF ERLENMEYER-PLOCHL AZLACTONES PROMOTED BY 5-SULFOSALICYLIC ACID

摘要

5-Sulfosalicylic acid was found as an efficient catalyst in the synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones by condensation and cyclodehydration of aromatic aldehydes with hippuric acid and acetic anhydride at room temperature. The catalyst was easily recycled from the filtrate via evaporation of solvent and reused. This process is green, simple to handle, commercially available starting materials and catalyst, mild conditions, as well as it does not require to hazardous organic solvents, heating, and microwave and ultrasound irradiations.