SYNTHESIS OF (-)-ISOSOLENOPSIN USING DIASTEREOSELECTIVE AMINOPALLADATION

摘要

Concise synthesis of (-)-isosolenopsin, a piperidine alkaloid isolated from the fire ants (Solenopsis) was achieved. 2,6-Disubstituted piperidine ring of (-)-isosolenopsin was constructed using diastereoselective aminopalladation. Chain elongation using Grubbs 2nd catalyst followed by reduction of double bond and deprotection of the Boc group afforded (-)-isosolenopsin.