RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE

摘要

A facile synthesis of hydroxymethylated N-aryl-azaindoles was developed via a Ru(II)-catalyzed regioselective C-H addition to paraformaldehyde. The reaction is compatible with air, shows high functional group tolerance and regioselectivity, and is an environmentally benign method without any undesired byproduct.