PREPARATION OF NEW NITROGEN-BRIDGED HETEROCYCLES.64.A SMOOTH FORMATION OF 2,4-DIARYLPYRIDO[2,3-6]INDOLIZINE-10-CARBONITRILE DERIVATIVES

摘要

The syntheses of the title compounds from the reactions of 2-amino-3-(arylcarbonyl)indolizine-1-carbonitriles with various acetophenones in the presence of strong base were investigated.When the reactions were carried out between 2-aminoindolizines and 1.2-equimolar amounts of acetophenones,the yields for the target molecules were low or very low.However,when a large excess of acetophenones were used without any solvent or in as small as amount of solvent as possible,their yields were considerably improved.The smooth hydrolysis of the 10-cyano group to the carbamoyl one was also observed.