ISOLATION OF INOHANALACTONE, A gamma-BUTYROLACTONE, FROM NOCARDIA INOHANENSIS IFM0092(T)

摘要

Because research on the genus Nocardia has not progressed as compared to the extensively studied genus Streptomyces, Nocardia is considered as a useful undeveloped resource for exploring natural products. In this study, a new gamma-butyrolactone derivative, named inohanalactone (1), was isolated from Nocardia inohanensis IFM0092(T). Inohanalactone possesses an aliphatic side chain containing 8 carbons, a vicinal diol, and a cis double bond. Inohanalactone was produced by N. inohanensis IFM0092T in the modified Czapek-Dox medium, whereas it was not produced in other media such as Nutrient broth, Waksman, and Yeast-Malt-Glucose media.