THE ONE-POT SYNTHESIS OF PYRIDINE DERIVATIVES FROM THE CORRESPONDING 1,5-DICARBONYL COMPOUNDS

摘要

The optimization of the one-pot, acid-promoted synthesis of pyridine and alkylpyridine derivatives from simple alkyl-1,5-dicarbonyl derivatives and via the corresponding oxime intermediate is described. Of all the combinations of and solvents tested, the use of HCl in refluxing dioxane was found to result in the highest chemical yields. Twelve pyridines were prepared using this method.