SYNTHESES OF PHOSPHONATO-SUBSTITUTED AZOLO[1,2,4]-TRIAZINES WITH POTENTIAL BIOMEDICAL APPLICATIONS

摘要

The syntheses of [1,2,4]triazino[4,3-b][1,2,4]indazol-3-yl-phosphonic acid dialkyl esters (5-7),pyrazolo[3,2-c][1,2,4]triazin-3-ylphosphonic acid dialkyl esters (13-15)are desribed.The treatment of 7-methylpyrazolo[1,2,4]triazin derivatives (9c,d,11c-e)with N-bromo-or N-iodosuccinimide yields the corresponding 8-halogen compounds (19a-h).The 8-iodo derivatives could be coupled with phenylacetylene.