SYNTHESIS OF 4-ARYLISOQUINOLINE-1(2H)-THIONE DERIVATIVES BY SODIUM HYDRIDE-MEDIATED CYCLIZATIONS OF 2-(1-ARYLETHENYL)BENZOTHIOAMIDES

摘要

A new and facile method for the general preparation of isoquinoline-1(2H)-thione derivatives has been developed. Thus, the sodium hydride-mediated cyclization of N-substituted 2-(1-arylethenyl)benzothioamides, which are derived from the reaction of 2-(1-arylethenyl)phenyllithiums with isothiocyanates, gives 2-substituted 4-aryl-3,4-dihydroisoquinoline-1(2H)-thiones. In addition, the use of N-substituted 2-(1-aryl-2-methoxyethenyl)benzothioamides from 2-(1-aryl-2-methoxyethenyl)phenyllithiums and isothiocyanates affording 2-substituted 4-arylisoquinoline-1(2H)-thiones is described.