Adverse drug reactions to antiretroviral drugs and impact on treatment adherence among HIV patients in northwestern Nigeria

摘要

Background Adverse drug reactions (ADRs) related to antiretroviral therapy (ART) have been a healthcare concern in the management of HIV. Information relating to ADR prevalence and its contribution to medication adherence is still limited in the northwestern part of Nigeria. Objective The aim of this study was to determine the prevalence of ADRs related to ART use, and its association with non-adherence to treatment. Methods A prospective observational study was conducted among HIV patients receiving ART at the ART unit of a specialist hospital in Jigawa State, the Northwestern region of Nigeria. Data were collected using patient interview and medical case folders. Patients were followed for 6?months for ADR monitoring. ADR causality was assessed using the WHO causality assessment. Results Of the 167 patients in the study, 98 (58.7%) reported experiencing ADRs from ART use. Thirty-nine (44.8%) of the ADRs were possible, 16 (18.4%) were probable, 23 (26.4%) were unlikely, and 9 (10.3%) were conditional. Forty-one (47.1%) of the ADRs were mild, 45 (51.7%) were moderate, and 1 (1.2%) was severe. The most commonly reported ADRs were related to the CNS (163, 52%). ADRs led to non-adherence in 16 patients (16.3%) in the study (Chi-square?=?12.1; p ?