Feature-Tracking Global Longitudinal Strain Predicts Death in a Multicenter Population of Patients With Ischemic and Nonischemic Dilated Cardiomyopathy Incremental to Ejection Fraction and Late?Gadolinium Enhancement

Simone Romano; Robert M. Judd; Raymond J. Kim; Han W. Kim; Igor Klem; John F. Heitner; Dipan J. Shah; Jennifer Jue; Brent E. White; Raksha Indorkar; Chetan Shenoy; Afshin Farzaneh-Far

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Feature-Tracking Global Longitudinal Strain Predicts Death in a Multicenter Population of Patients With Ischemic and Nonischemic Dilated Cardiomyopathy Incremental to Ejection Fraction and Late?Gadolinium Enhancement

机译：功能跟踪全局纵向菌株预测缺血性和非缺血性扩张的患者患者的多中心群体的死亡，射血分数和晚期？钆增强

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机译：<！[CDATA [目录本研究的目的是评估心脏磁共振（CMR）特征跟踪衍生的全局纵向菌株（GLS）在缺血性和非缺血扩张的心肌病患者大型多中心群体中的预后值。背景技术使用超声心动图或CMR特征跟踪对GLS进行心肌纤维变形的评估已经显示出在单中心研究中提供预后信息增量（EF）的预后信息。鉴于CMR越来越多地使用CMR来评估左心室（LV）功能障碍的人，我们假设特征跟踪衍生的GLS可以在缺血性和非缺血扩张的心肌病患者的多中心群中提供独立的预后信息。在本研究中纳入了患有EF的4中的400.医疗中心的方法调节患者。特征跟踪GLS由3个长轴调用视图计算。主要终点是全部导致死亡。 Cox比例危害回归建模用于检查GLS和死亡之间的关联。在嵌套模型中评估了GLS的增量预后值。本研究中的1,012名患者，133岁在中位随访4.4岁。通过Kaplan-Meier分析，GLS Tertiles恶化的死亡风险显着增加（Log-Rank P？<0.0001）。 GLS中的每一个1％的增长与临床和成像危险因素调整后的死亡风险增加89.1％有关，包括EF和晚期钆增强（LGE）（危险比[HR]：1.891 /％; P？<0.001）。在该模型中添加GLS导致C统计（0.628至0.867;p≤<0.0001）显着改善。连续净重新分类改善（NRI）为1.148（95％置信区间：0.996至1.318）。在调整临床和成像危险因素（包括EF和晚期钆增强）的缺血（HR：1.942 /％per％; p-<0.001）和非缺血扩张的心肌病亚组（HR：2.101 /％; P <0.101）后，GLS独立相关？<0.001）。结论CMR特征跟踪衍生的GLS是一种强大的独立预测，在缺血性或非缺血扩张的患者患者的多中心群体中，常见的临床和CMR风险因素增加，包括EF和LGE。

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《JACC. Cardiovascular imaging.》 |2018年第10期|共11页
作者
Simone Romano; Robert M. Judd; Raymond J. Kim; Han W. Kim; Igor Klem; John F. Heitner; Dipan J. Shah; Jennifer Jue; Brent E. White; Raksha Indorkar; Chetan Shenoy; Afshin Farzaneh-Far;
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作者单位

Division of Cardiology Department of Medicine University of Illinois at Chicago;

Division of Cardiology Department of Medicine Duke University;

Division of Cardiology Department of Medicine Duke University;

Division of Cardiology Department of Medicine Duke University;

Division of Cardiology Department of Medicine Duke University;

Department of Cardiology New York Methodist Hospital;

Houston Methodist DeBakey Heart &

Vascular Center;

Division of Cardiology Department of Medicine University of Illinois at Chicago;

Division of Cardiology Department of Medicine University of Illinois at Chicago;

Division of Cardiology Department of Medicine University of Illinois at Chicago;

Division of Cardiology Department of Medicine Duke University;

Division of Cardiology Department of Medicine University of Illinois at Chicago;

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正文语种 eng
中图分类诊断学;
关键词
cardiac magnetic resonance imaging; cardiomyopathy; feature tracking; global longitudinal strain; left ventricular function; mortality; prognosis;

机译：心脏磁共振成像;心肌病;特征跟踪;全局纵向应变;左心室功能;死亡率;预后;

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1. Feature-Tracking Global Longitudinal Strain Predicts Death in a Multicenter Population of Patients With Ischemic and Nonischemic Dilated Cardiomyopathy Incremental to Ejection Fraction and Late?Gadolinium Enhancement [J] . Simone Romano, Robert M. Judd, Raymond J. Kim, JACC. Cardiovascular imaging. . 2018,第10期

机译：功能跟踪全局纵向菌株预测缺血性和非缺血性扩张的患者患者的多中心群体的死亡，射血分数和晚期？钆增强
2. Response by Jablonowski et al to Letter Regarding Article, "Cardiovascular Magnetic Resonance to Predict Appropriate Implantable Cardioverter Defibrillator Therapy in Ischemic and Nonischemic Cardiomyopathy Patients Using Late Gadolinium Enhancement Border Zone: Comparison of Four Analysis Methods" [J] . Jablonowski Robert, Chaudhry Uzma, van der Pals Jesper, Circulation. Cardiovascular imaging . 2018,第1期

机译：Jablonowski等对文章的回应，“心血管磁共振预测适当的植入心脏病患者在使用后期钆增强边界区的缺血性和无际血肿性心肌病疗法：四种分析方法的比较”
3. Letter by Guaricci et al Regarding Article, "Cardiovascular Magnetic Resonance to Predict Appropriate Implantable Cardioverter Defibrillator Therapy in Ischemic and Nonischemic Cardiomyopathy Patients Using Late Gadolinium Enhancement Border Zone: Comparison of Four Analysis Methods" [J] . Guaricci Andrea I., Muscogiuri Giuseppe, Pontone Gianluca Circulation. Cardiovascular imaging . 2018,第1期

机译：Guaricci等人关于物品，“心血管磁共振预测适当的植入心脏病患者在缺血性和非血型血模病患者中使用晚钆增强边界区：四种分析方法的比较”
4. Three dimensional reconstruction of blood flow within the left ventricle: comparison of normal, dilated cardiomyopathy and reduced ejection fraction [C] . Boonchieng, E., Soble, . 2001

机译：左心室内血流的三维重建：正常，扩张型心肌病和射血分数降低的比较
5. The Selvester QRS score as a predictor of cardiac events in nonischemic dilated cardiomyopathy [D] . Hiraiwa Hiroaki, 平岩宏章 2019

机译：Selvester QRS评分可预测非缺血性扩张型心肌病的心脏事件
6. Feature-tracking global longitudinal strain predicts death in a multicenter population of patients with ischemic and non-ischemic dilated cardiomyopathy incremental to ejection fraction and late gadolinium enhancement [O] . Simone Romano, Robert M Judd, Raymond J Kim, -1

机译：特征追踪全球纵向应变预测多中心缺血和非缺血性扩张型心肌病患者的死亡射血分数和晚期enhancement增强
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Feature-Tracking Global Longitudinal Strain Predicts Death in a Multicenter Population of Patients With Ischemic and Nonischemic Dilated Cardiomyopathy Incremental to Ejection Fraction and Late?Gadolinium Enhancement

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