Comparison of Tightly Controlled Dose Reduction of Biologics With Usual Care for Patients With Psoriasis A Randomized Clinical Trial

Atalay Selma; van den Reek Juul M. P. A.; den Broeder Alfons A.; van Vugt Lieke J.; Otero Marisol E.; Njoo Marcellus D.; Mommers Johannes M.; Ossenkoppele Paul M.; Koetsier Marjolein I.; Berends Maartje A.; van de Kerkhof Peter C. M.; Groenewoud Hans M. M.; Kievit Wietske; de Jong Elke M. G. J.

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Comparison of Tightly Controlled Dose Reduction of Biologics With Usual Care for Patients With Psoriasis A Randomized Clinical Trial

机译：牛肝病患者对牛皮癣患者进行严格控制剂量减少生物制剂的比较

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摘要

This noninferiority randomized clinical trial investigates whether dose reduction of biologics for stable psoriasis is noninferior to usual care in patients with plaque psoriasis.

机译：这种非流体性随机临床试验研究了稳定牛皮癣的生物制剂剂量还原是否是斑块牛皮癣患者的常用护理。

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来源
《JAMA dermatology》 |2020年第4期|共8页
作者
Atalay Selma; van den Reek Juul M. P. A.; den Broeder Alfons A.; van Vugt Lieke J.; Otero Marisol E.; Njoo Marcellus D.; Mommers Johannes M.; Ossenkoppele Paul M.; Koetsier Marjolein I.; Berends Maartje A.; van de Kerkhof Peter C. M.; Groenewoud Hans M. M.; Kievit Wietske; de Jong Elke M. G. J.;
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作者单位

Radboud Univ Nijmegen Med Ctr Dept Dermatol Rene Descartesdreef 1 NL-6525 GL Nijmegen;

Radboud Univ Nijmegen Med Ctr Dept Dermatol Rene Descartesdreef 1 NL-6525 GL Nijmegen;

Sint Maartensklin Dept Rheumatol Nijmegen Netherlands;

Radboud Univ Nijmegen Med Ctr Dept Dermatol Rene Descartesdreef 1 NL-6525 GL Nijmegen;

Radboud Univ Nijmegen Med Ctr Dept Dermatol Rene Descartesdreef 1 NL-6525 GL Nijmegen;

Ziekenhuis Groep Twente Dept Dermatol Hengelo Netherlands;

Sint Anna Ziekenhuis Dept Dermatol Geldrop Netherlands;

Ziekenhuis Grp Twente Dept Dermatol Almelo Netherlands;

Gelre Ziekenhuizen Dept Dermatol Apeldoorn Netherlands;

Slingelandziekenhuis Dept Dermatol Doetinchem Netherlands;

Radboud Univ Nijmegen Med Ctr Dept Dermatol Rene Descartesdreef 1 NL-6525 GL Nijmegen;

Sint Maartensklin Dept Rheumatol Nijmegen Netherlands;

Radboud Univ Nijmegen Med Ctr Dept Hlth Evidence Nijmegen Netherlands;

Radboud Univ Nijmegen Med Ctr Dept Dermatol Rene Descartesdreef 1 NL-6525 GL Nijmegen;

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正文语种 eng
中图分类皮肤病学与性病学;
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专利

1. Comparison of Tightly Controlled Dose Reduction of Biologics With Usual Care for Patients With Psoriasis A Randomized Clinical Trial [J] . Atalay Selma, van den Reek Juul M. P. A., den Broeder Alfons A., JAMA dermatology . 2020,第4期

机译：牛肝病患者对牛皮癣患者进行严格控制剂量减少生物制剂的比较
2. A multi-center, randomized controlled clinical trial, cost-effectiveness and qualitative research of electroacupuncture with usual care for patients with non-acute pain after back surgery: study protocol for a randomized controlled trial [J] . Byung-Cheul Shin, Jae-Heung Cho, In-Hyuk Ha, Trials . 2018,第1期

机译：多中心，随机对照临床试验，成本效益和定性研究电针疗法对背部手术后非急性疼痛患者的常规护理：一项随机对照试验的研究方案
3. Fixed Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control in Patients With Mild to Moderate Hypertension in Sri Lanka A Randomized Clinical Trial [J] . Webster Ruth, Salam Abdul, De Silva H. Asita, JAMA: the Journal of the American Medical Association . 2018,第6期

机译：固定低剂量三重组合抗高血压药物对斯里兰卡轻度至中度高血压患者的血压控制常规护理患者随机临床试验
4. High Dose Vitamin E Supplementation and Mortality: Discussion of the Results of a Meta-analysis of Randomized Controlled Clinical Trial [C] . International Society for Free Radical Research . 2006

机译：高剂量维生素E补充和死亡率：讨论随机对照临床试验的荟萃分析结果
5. Tele-Mindfulness for Dementia's Family Caregivers: A Randomized Trial with a Usual Care Control Group [D] . Zarei, Shadi. 2018

机译：痴呆症的家庭护理人员的远程态度：随机保育小组的随机试验
6. Tight controlled dose reduction of biologics in psoriasis patients with low disease activity: a randomized pragmatic non-inferiority trial [O] . Selma Atalay, Juul M. P. A. van den Reek, Lieke J. van Vugt, 2017

机译：疾病活动度低的牛皮癣患者的生物制剂的严格控制剂量降低：一项随机的实用的非自卑性试验
7. Tight controlled dose reduction of biologics in psoriasis patients with low disease activity: a randomized pragmatic non-inferiority trial [O] . Atalay S., Reek J.M.P.A. van den, Vugt L.J. van, 2017

机译：疾病活动度低的牛皮癣患者严格控制剂量的生物制剂的使用：一项随机，实用，不自卑的试验

Comparison of Tightly Controlled Dose Reduction of Biologics With Usual Care for Patients With Psoriasis A Randomized Clinical Trial

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