Vilsmeier Reaction in a Series of N-Substituted Aminoacetic Acids

摘要

The capability of monosubstituted acetic acids for reacting with the Vilsmeier-Haack reagent(POCl_3;DMF)[1-3] to give 2-substituted-3-(dimethyl-amino)acroleins was shown for the first time by Arnold [4].The unique structure and high reactivity of resulting salts [5],whose alkaline hydrolysis led to the formation of a three-carbon dicarbonyl synthon,made it possible to synthesize and study in detail the structure and chemical properties of a large number of previously unknown compounds capable of forming bis(chelate)and macrocyclic metal complexes [6-8].