Dendritic cells in allergen-specific immunotherapy.

摘要

Allergen immunotherapy is a well-known long-term treatment for allergic diseases that aims to provide specific tolerance in patients with specifically diagnosed sensitizations. The two main mechanisms identified which go along with this treatment are the shift from a Th2 response to a modified Th1 response and the shift from IgE production to IgG production, as well as increased IL-10 and transforming growth factor beta (TGF-beta) release by T cells and activation of regulatory T-cell subtypes.