Synthesis and in Vitro Antimicrobial and Cytotoxicity Activities of 2-[(2-nitro-l-phenylalkyl)thio]benzoic Acid Derivatives

摘要

In this research 14 compounds were tested for their antimicrobial activity.The synthesis of 7 compounds corresponding to 2-[(2-nitro-l-phenyl-propyl)thio]benzoic acids 4 has not been reported before and 7 compounds corresponding to 2-[(2-nitro-l-phenyl-ethyl)thio]benzoic acid 3 were reported by our research group.The antibacterial activity of the title compounds was evaluated by 2 Gram (+) (Staphylococcus aureus,Bacillus subtilis) and 2 Gram (-)(Pseudomonas aeruginosa,Escherichia coli) microorganisms.The antifungal activity of the compounds was also determined against yeast-like fungi (Candida albicans,C.krusei).For antibacterial activity,ampicillin and for antifungal activity,fluconazole and ketoconazole have been used as reference compounds.All of the 2-[(2-nitro-l-phenyl-ethyl)thio]benzoic acid 3 derivatives were more active than the reference compound ketoconazole in the antifungal activity test.The title compounds were also screened by consecutive dilution to explore their toxicity to a Vero cell line.Except for 3d and 3e all of the compounds 3 exhibited lower toxicity than ketoconazole.