Synthesis and Isolation of New Regioisomeric 4-Thiazolidinones and Their Anticonvulsant Activity

摘要

Two regioisomer series,2-(3-ethyI-4(3H)-quinazolinone-2-ylmercaptoacetylhydrazono)-3-alkyl/3-aryl-5-methyl-4-thiazolidinones (12-21) and 2-arylimino-3-(3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetyla-mino)-5-methyl-4-thiazolidinones (22-26),were synthesized by the cyclization of l-(3-ethyl-4(3H)-quina-zolinone-2-ylniercaptoacetyl)-4-alkyl/aryl thiosemicarbazides (1-11) with ethyl 2-bromopropionate in the presence of anhydrous sodium acetate in anhydrous ethanolic medium.The structures of 12-26 were confirmed by analytical and spectral data (IR,~1-NMR and EIMS).Selected members of the thiosemicarbazides and thiazolidinones were subjected to anticonvulsant activity tests by the National Institute of Neurological Disorders and Stroke MD,USA.