DFT studies of the drug carrier of anti-migraine (sumatriptan) on nano-graphene oxide (NGO) and graphene oxide/polyethylene glycol polymer nano-composite

摘要

Migraine headaches are one of the most serious disorders. Sumatriptan, the selective agonist of the 5-HT1(B/D), receptor, is the first choice for the treatment of migraine attacks that its oral bioavailability is less than 15%. The aim is to prepare and evaluate a new soluble oral film formulation of sumatriptan for the rapid treatment of migraine attacks and cluster headaches.