Vitamin D suppresses lipopolysaccharide-induced inflammatory response in vascular smooth muscle cells via inhibition of the p38 MAPK signaling pathway

摘要

Inflammation and vascular smooth muscle cells (VSMCs) play key roles in the development of many cardiovascular diseases (CVDs). Although vitamin D decreases the risks of inflammation related diseases including CVDs, the links between vitamin D, VSMCs and vascular inflammation remainedunclear. In this study, we investigated the anti-inflammatory effect and signaling pathways of vitamin D in lipopolysaccharide (LPS)-induced VSMCs. 1,25(OH)2D3 treatment inhibited the significant upregulation of COX-2, PGE2, TNF-α and IL-6 and p38 phosphorylationinduced by LPS in A10 cells. Blocking p38 signaling attenuated the inhibitory effect of 1,25(OH)2D3 on the upregulation of COX-2 and phosphorylation of p38. These results indicate 1,25(OH)2D3 suppresses inflammatory response in LPS-induced VSMCsthrough p38 MAPK signaling pathway.