Lymphoid neoplasms of the sinonasal tract and their differential diagnoses

摘要

Many types of lymphoid neoplasms have been reported involving the sinonasal region including aggressive and indolent B-cell lymphomas, T/NK cell lymphomas and plasma cell neoplasms. They account for a small percentage of all lymphomas but as a whole is the second most common malignancy in the sinonasal region. Clinically and morphologically, they can mimic non-neoplastic and non-hematolymphoid malignant lesions in this region and must be included in the differential diagnoses when a sinonasal lesion is encountered. This article describes the histopathologic and molecular features of diffuse large B-cell lymphoma and extranodal NK/T cell lymphoma, the two main types of lymphomas found in the sinonasal tract, as well as plasmacy-toma and plasmablastic lymphoma, which tend to locate in the head and neck region, and reviews the main differential diagnoses.