Adiposity and family history of type 2 diabetes in an admixed population of adolescents: Associations with insulin sensitivity, beta-cell function, and hepatic insulin extraction in BRAMS study

Camilo Daniella F.; Vasques Ana Carolina J.; Hayashi Keila; Tura Andrea; da Silva Cleliani de Cassia; Zambon Mariana P.; Monteiro Antonio Maria Angela R. de G.; Geloneze Bruno

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Adiposity and family history of type 2 diabetes in an admixed population of adolescents: Associations with insulin sensitivity, beta-cell function, and hepatic insulin extraction in BRAMS study

机译：2型糖尿病患者的脂肪素和家族史，患有胰岛素敏感性，β细胞功能和肝脏胰岛素提取的关联

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Aims: Insulin resistance and beta-cell dysfunction manifest differently across racial/ethnic groups, and there is a lack of knowledge regarding the pathophysiology of type 2 diabetes mellitus (T2DM) for ethnically admixed adolescents. This study aimed to investigate the influence of adiposity and family history (FH) of T2DM on aspects of insulin sensitivity, beta-cell function, and hepatic insulin extraction in Brazilian adolescents.

机译：目的：胰岛素抵抗和β-细胞功能障碍在种族/族群中不同，缺乏关于种族混合的青少年2型糖尿病（T2DM）的病理生理学的知识。本研究旨在探讨T2DM对胰岛素敏感性，β细胞功能和巴西青少年肝胰岛素萃取方面的影响和家族史（FH）的影响。

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《Diabetes research and clinical practice》 |2018年第2018期|共11页
作者
Camilo Daniella F.; Vasques Ana Carolina J.; Hayashi Keila; Tura Andrea; da Silva Cleliani de Cassia; Zambon Mariana P.; Monteiro Antonio Maria Angela R. de G.; Geloneze Bruno;
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作者单位

Univ Campinas Unicamp Lab Invest Metab &

Diabet Limed Gastroenterol Diag &

Res Ctr Gastroctr;

Univ Campinas Unicamp Lab Invest Metab &

Diabet Limed Gastroenterol Diag &

Res Ctr Gastroctr;

Univ Campinas Unicamp Lab Invest Metab &

Diabet Limed Gastroenterol Diag &

Res Ctr Gastroctr;

CNR Metab Unit Inst Neurosci Padua Italy;

Univ Campinas Unicamp Lab Invest Metab &

Diabet Limed Gastroenterol Diag &

Res Ctr Gastroctr;

Univ Campinas Unicamp Fac Med Sci Postgrad Program Child &

Adolescent Hlth Campinas SP Brazil;

Univ Campinas Unicamp Fac Med Sci Postgrad Program Child &

Adolescent Hlth Campinas SP Brazil;

Univ Campinas Unicamp Lab Invest Metab &

Diabet Limed Gastroenterol Diag &

Res Ctr Gastroctr;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
Hyperglycemic clamp; Insulin sensitivity; Insulin secretion in vivo; Adolescents; Heredity; Obesity;

机译：高血糖夹;胰岛素敏感性;体内胰岛素分泌;青少年;遗传;肥胖;
入库时间 2022-08-20 08:20:06

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1. Adiposity and family history of type 2 diabetes in an admixed population of adolescents: Associations with insulin sensitivity, beta-cell function, and hepatic insulin extraction in BRAMS study [J] . Camilo Daniella F., Vasques Ana Carolina J., Hayashi Keila, Diabetes research and clinical practice . 2018,第期

机译：2型糖尿病患者的脂肪素和家族史，患有胰岛素敏感性，β细胞功能和肝脏胰岛素提取的关联
2. The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing beta-Cell Function and Hepatic Insulin Sensitivity [J] . Cropano Catrina, Santoro Nicola, Groop Leif, Diabetes care . 2017,第8期

机译：TCF7L2基因的RS7903146变体通过损害β细胞功能和肝胰岛素敏感性，增加了肥胖青少年前肥胖/型糖尿病的风险
3. Association of artificially sweetened and sugar-sweetened soft drinks with beta-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study [J] . European journal of nutrition . 2020,第4期

机译：具有β细胞功能，胰岛素敏感性和2型糖尿病的人工加糖和糖加糖甜味的软饮料：Maastricht研究
4. Boolean network modeling of beta-cell apoptosis and insulin resistance in type 2 diabetes mellitus [C] . Asia Pacific Bioinformatics Conference . 2019

机译：Beta细胞凋亡和2型糖尿病胰岛素抵抗的布尔网络建模
5. Effects of vitamin D genes on measures of insulin secretion, insulin sensitivity and adiposity: An ancillary study to the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. [D] . Engelman, Corinne Denise. 2006

机译：维生素D基因对胰岛素分泌，胰岛素敏感性和肥胖程度的影响：胰岛素抵抗动脉粥样硬化研究（IRAS）家庭研究的一项辅助研究。
6. Achieving ADA/ISPAD Clinical Guideline Goals Is Associated with Higher Insulin Sensitivity and Cardiopulmonary Fitness in Adolescents with Type 1 Diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies [O] . Petter Bjornstad, Melanie Cree-Green, Amy Baumgartner, -1

机译：在1型糖尿病青少年中实现ADA / ISPAD临床指南目标与更高的胰岛素敏感性和心肺适应性相关：1型和2型糖尿病患者对胰岛素抵抗的结果（抗性）和甲福明对1型糖尿病患者心血管功能的影响。糖尿病（EMERALD）研究
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Adiposity and family history of type 2 diabetes in an admixed population of adolescents: Associations with insulin sensitivity, beta-cell function, and hepatic insulin extraction in BRAMS study

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