Initial severity and antidepressant efficacy for anxiety disorders, obsessive‐compulsive disorder, and posttraumatic stress disorder: An individual patient data meta‐analysis

Vries Ymkje Anna; Roest Annelieke M.; Burgerhof Johannes G. M.; Jonge Peter

摘要

Background >It has been suggested that antidepressant benefits are smaller for mild than severe depression. Because antidepressants are also used for anxiety disorders, obsessive‐compulsive disorder (OCD), and posttraumatic stress disorder (PTSD), we examined the influence of severity for these disorders. </section> <section xml:id="da22737-sec-0020"> <title type="main">Methods >We used individual patient data of eight trials (3,430 participants) for generalized anxiety disorder (GAD); four trials (1,195 participants) for social anxiety disorder (SAD); four trials (1,132 participants) for OCD; three trials (1,071 participants) for PTSD; and 10 trials (2,151 participants) for panic disorder (PD). Mixed‐effects models were used to investigate an interaction between severity and treatment group. </section> <section xml:id="da22737-sec-0030"> <title type="main">Results >For GAD and PD, severity moderated antidepressant efficacy. The antidepressant–placebo difference was 1.4 (95% CI: 0.4–2.5; SMD: 0.21) Hamilton Anxiety Rating Scale (HAM‐A) points for participants with mild GAD (baseline HAM‐A?=?10), increasing to 4.0 (3.4–4.6; SMD: 0.45) or greater for severely ill participants (HAM‐A?≥?30). For PD, the difference was 0.4 (0.3–0.6) panic attacks/2?weeks for participants with 10 panic attacks/2?weeks at baseline, increasing to 4.7 (3.0–6.4) for participants with 40. For SAD, OCD, and PTSD, no interaction was found. Across severity levels, the differences were 16.1 (12.9–19.3; SMD: 0.59) Liebowitz Social Anxiety Scale points, 3.4 (2.5–4.4, SMD: 0.39) Yale–Brown Obsessive‐Compulsive Scale points, and 10.3 (6.9–13.6; SMD: 0.41) Clinician‐Administered PTSD Scale points. </section> <section xml:id="da22737-sec-0040"> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <第XML：ID =“da22737-sec-0010”> <标题类型=“main”>背景</ title> >它已经提出了抗抑郁效应比严重抑郁症更小。由于抗抑郁药也用于焦虑症，强迫性疾病（OCD）和错误后应激障碍（PTSD），所以我们检查了这些疾病的严重程度的影响。</ p> </ section> <section XML：ID =“ DA22737-SEC-0020“> <标题类型=”main“>方法</ title> >我们使用了八项试验（3,430名参与者）的个别患者数据以进行广泛性焦虑症（GAD）;四项试验（1,195名参与者）的社交焦虑症（悲伤）;四项试验（1,132名参与者）的OCD;三项试验（1,071名参与者）为应激障碍;和10项试验（2,151名参与者）用于恐慌症（PD）。混合效果模型用于研究严重程度和治疗组之间的相互作用。</ p> </ section> <section xml：id =“da22737-sec-0030”> <标题类型=“main”>结果</标题> >用于GAD和PD，严重程度的调节抗抑郁效果。抗抑郁 - 安慰剂差异为1.4（95％CI：0.4-2.5; SMD：0.21）汉密尔顿焦虑评级规模（HAM-A）与轻度GAD的参与者（基线HAM-A？= 10），增加到4.0（ 3.4-4.6; SMD：0.45）对于严重生病的参与者（Ham-A？≥30）或更大。对于PD，差异为0.4（0.3-0.6）恐慌攻击/ 2？对于10个恐慌攻击/ 2的参与者，基线周数为4.7（3.0-6.4），为40人增加4.7（3.0-6.4）。对于悲伤，强迫，和PTSD，没有发现互动。跨越严重程度，差异为16.1（12.9-19.3; SMD：0.59）Liebowitz社会焦虑比分，3.4（2.5-4.4，SMD：0.39）耶鲁棕色强迫率刻度点，10.3（6.9-13.6; SMD ：0.41）临床医生施用的可击办点标度点。</ p> </ section> <section XML：ID =“DA22737-SEC-0040”> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32884/'>《Depression and anxiety 》</a> <b style="margin: 0 2px;">|</b><span>2018年第6期</span><b style="margin: 0 2px;">|</b> <span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vries Ymkje Anna&option=202" target="_blank" rel="nofollow">Vries Ymkje Anna;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Roest Annelieke M.&option=202" target="_blank" rel="nofollow">Roest Annelieke M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Burgerhof Johannes G. M.&option=202" target="_blank" rel="nofollow">Burgerhof Johannes G. M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jonge Peter&option=202" target="_blank" rel="nofollow">Jonge Peter;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Interdisciplinary Center Psychopathology and Emotion regulation Department of PsychiatryUniversity of GroningenGroningen The Netherlands;</p> <p>Interdisciplinary Center Psychopathology and Emotion regulation Department of PsychiatryUniversity of GroningenGroningen The Netherlands;</p> <p>Department of EpidemiologyUniversity of GroningenGroningen The Netherlands;</p> <p>Interdisciplinary Center Psychopathology and Emotion regulation Department of PsychiatryUniversity of GroningenGroningen The Netherlands;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span>R749.72; </span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antidepressive agents&option=203" rel="nofollow">antidepressive agents;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=anxiety disorders&option=203" rel="nofollow">anxiety disorders;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=meta‐analysis&option=203" rel="nofollow">meta‐analysis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=obsessive‐compulsive disorder&option=203" rel="nofollow">obsessive‐compulsive disorder;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=panic disorder&option=203" rel="nofollow">panic disorder;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=posttraumatic stress disorder&option=203" rel="nofollow">posttraumatic stress disorder;</a> </p> <div class="translation"> 机译：诱捕剂;焦虑症;荟萃分析;强迫症;恐慌症;错误症; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025195544.html">Initial severity and antidepressant efficacy for anxiety disorders, obsessive‐compulsive disorder, and posttraumatic stress disorder: An individual patient data meta‐analysis</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vries Ymkje Anna&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Vries Ymkje Anna,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Roest Annelieke M.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Roest Annelieke M.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Burgerhof Johannes G. 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rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 董婷婷</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张成帅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张成帅</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张志强&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张志强</a> <span> <a href="/journal-cn-5797/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国心理卫生杂志 </a> </span> <span> . 2018</span><span> ,第001期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_guangxi-medical-journal_thesis/0201270544972.html">基于随访数据库系统的多形式个体化随访方案对2型糖尿病患者出院后不同阶段血糖控制的效果评价▲</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨小玲&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 杨小玲</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=袁丽&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,袁丽</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=古艳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,古艳</a> <span> <a href="/journal-cn-6597/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 广西医学 </a> </span> <span> . 2018</span><span> ,第021期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-2563_thesis/02022527415.html">缺血后适应对ST段抬高心肌梗死患者直接经皮冠状动脉介入治疗效果的影响:Meta分析</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=汪雁博&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 汪雁博</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=傅向华&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,傅向华</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=谷新顺&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,谷新顺</a> <span> <a href="/conference-cn-2563/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第七届华北长城心脏病学会议、河北省心血管病学2014年会暨第三届经前臂（桡/尺）动脉微创化冠脉介入治疗国际论坛 </a> <span> <span> . 2014</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020311459857.html">芳香化酶抑制剂用于绝经后激素依赖性乳腺癌患者新辅助内分泌治疗效果的Meta分析</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郭德阳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 郭德阳</a> <span> . 2016</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06130422983980.html">compound, pharmaceutical composition; use of the compound for the manufacture of a medicament for treating irritable bowel syndrome, treating pain or painful syndromes, treating urinary incontinence, treating depression, fibromyalgia, anxiety, panic disorder, agorophobia, pre-traumatic stress disorder, pre-dysphoric disorder menstrual disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, gilles de la tourette syndrome, vasomotor discharge, cocaine addiction, sexual dysfunction, personality threshold disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, shy drager syndrome, raynaud syndrome, parkinson's disease, and epilepsy, method of preparing a compound of structure (a), and Method of preparing a compound of structure (b)</a> <b>[P]</b> . <span> 外国专利：  BRPI0613031A2 </span> <span> . 2012-01-03</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：化合物，药物组合物;该化合物在制备用于治疗肠易激综合症，治疗疼痛或疼痛综合症，治疗尿失禁，治疗抑郁症，纤维肌痛，焦虑症，恐慌症，广场恐惧症，创伤前应激障碍，烦躁不安症，月经失调的药物中的用途，注意力缺陷障碍，强迫症，社交焦虑症，广泛性焦虑症，自闭症，精神分裂症，肥胖症，神经性厌食症，神经性贪食症，抽动秽语综合征，血管舒缩放电，可卡因成瘾，性功能障碍，人格阈障碍，纤维肌痛综合征，糖尿病性神经性疼痛，慢性疲劳综合症，害羞药物综合征，雷诺氏综合症，帕金森氏病和癫痫病，结构式（a）的化合物的制备方法和结构式（b）的化合物的制备方法 </span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130442532554.html">Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders</a> <b>[P]</b> . <span> 外国专利：  US6689816B2 </span> <span> . 2004-02-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：创伤后应激障碍，强迫症和相关神经精神病的治疗 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130447008123.html">Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders</a> <b>[P]</b> . <span> 外国专利：  US6391922B1 </span> <span> . 2002-05-21</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：创伤后应激障碍，强迫症和相关神经精神病的治疗 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025195544','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" 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