Establishment and application of predictive method for skin concentration of several compounds using skin permeation parameters

摘要

Determination of skin distribution or skin concentration of active ingredients is very important for useful and safety evaluations of topical drug formulations and cosmetics. A lot of experimental animals are presently used to determine their skin concentration, because only a set of data is obtained from one experimental run. Skin permeation and skin concentration profiles of chemical compounds obey the Fick's law of diffusion. Generally, their skin permeation can be expressed by two-layered membrane model consisted of stratum corneum and underlying viable epidermis and dermis. Thus, we aim to predict skin concentration of several compounds using their permeation parameters obtained from skin permeation experiment. Prediction method for the permeation parameters and skin concentration of chemical compounds was also considered from their physicochemical parameters such as octanol-water partition coefficient or solubility parameter.