Evaluation of dynamic contrast-enhanced MRI biomarkers for stratified cancer medicine: How do permeability and perfusion vary between human tumours?

摘要

AbstractBackgroundSolid tumours exhibit enhanced vessel permeability and fenestrated endothelium to varying degree, but it is unknown how this varies in patients between and within tumour types. Dynamic contrast-enhanced (DCE) MRI provides a measure of perfusion and permeability, the transfer constantKtrans, which could be employed for such comparisons in patients.AimTo test the hypothesis that different tumour types exhibit systematically differentKtrans.Materials and methodsDCE-MRI data were retrieved from 342 solid tumours in 230 patients. These data were from 18 previous studies, each of which had had a different analysis protocol. All data were reanalysed using a standardised workflow using an extended Tofts model. A model of the posterior density of medianKtranswas built assuming a log-normal distribution and fitting a simple Bayesian hierarchical model.Results12 histological tumour types were included. In glioma, medianKtranswas 0.016min