Simultaneous measurement of total water content and myelin water fraction in brain at 3 T using a T-2 relaxation based method

摘要

Purpose: This work demonstrates the in vivo application of a T-2 relaxation based total water content (TWC) measurement technique at 3 T in healthy human brain, and evaluates accuracy using simulations that model brain tissue. The benefit of using T2 relaxation is that it provides simultaneous measurements of myelin water fraction, which correlates to myelin content.