The origin of ~(31)P MR signal at 5.35 ppm in patients with critical limb ischemia

摘要

A group of diabetic patients with limb ischemia was studied by rest and dynamic ~(31)P MRS. An unknown intensive signal with the mean chemical shift of 5.3 ppm (labeled as Pi~2) was observed in calf muscle spectra in several patients (Fig 1). Recently, the signal with a similar chemical shift has been assigned to inorganic phosphate (Pi) from mitochondrial and other phosphate alkaline pools1, 2. Another candidate to explain the presence of the unknown signal is glucose-1-phosphate (G1P).