Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy

摘要

Objective: To compare the level of serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1), and neonatal outcome in early onset preeclampsia (EO-PE), late onset preeclampsia (LO-PE), and normal pregnancy (NP).Methods: In this prospective observational case control study, HO-1 and sFlt-1 levels were measured in blood samples within 24h of hospital admission. Preeclampsia cases were divided into two groups based on gestational age at delivery: EO-PE (34weeks) and LO-PE (34weeks). A total of 45 patients were involved in this study.Result: Maternal serum level of sFlt-1 was higher in EO-PE than LO-PE and NP groups (meanSD; 14.50 +/- 17.12ng/ml vs 5.20 +/- 6.69ng/ml vs 2.72 +/- 1.2ng/ml [p=0.020]. Maternal serum level of HO-1 was not different between EO-PE, LO-PE, and NP groups (p=0.681). Birthweights were significantly lower in the EO-PE group compared with the LO-PE and NP groups (1580 +/- 536g vs 2635 +/- 578g vs 3010 +/- 371g [p=0.000]). The rate of small for gestational age infant (26.7% vs 6.7% vs 0%; p=0.046) and perinatal death (20% vs 0 vs 0; p=0.037) was also significantly higher in EO-PE compared to LO-PE and NP. The maternal sFlt-1 level was negatively correlated with birthweight (p=0.006; CC=-0.445).Conclusion: This study did not find a correlation between maternal HO-1 levels and sFlt-1 levels. Maternal serum sFLt-1 levels in preeclampsia were higher in EO-PE and were associated with a worse perinatal outcome.