Risk factors and outcomes of pyogenic liver abscess in adult liver recipients: a matched case-control study

摘要

BackgroundAdult liver recipients (ALR) differ from the general population with pyogenic liver abscess (PLA) as they exhibit: reconstructed biliary anatomy, recurrent hospitalizations, poor clinical condition and are subjected to immunosuppression. The aim of this study was to identify risk factors associated with PLA in ALR and to analyze the management experience of these patients. MethodsBetween 1996 and 2016, 879 adult patients underwent liver transplantation (LT), 26 of whom developed PLA. Patients and controls were matched according to the time from transplant to abscess in a 1 to 5 relation. A logistic regression model was performed to establish PLA risk factors considering clusters for matched cases and controls. Risk factors were identified and a multivariate regression analysis performed. ResultsPatients with post-LT PLA were more likely to have lower BMI (p?=?0.006), renal failure (p?=?0.031) and to have undergone retransplantation (p?=?0.002). A history of hepatic artery thrombosis (p?=?0.010), the presence of Roux en-Y hepatojejunostomy (p?