Targeting CSPG4 for isolation of melanoma cell-derived exosomes from body fluids

摘要

This manuscript describes the functional properties of the exosomes released from melanoma cells. It details the characteristics of the tumor antigen chondroitin sulfate proteoglycan?4 (CSPG4), which is used as a?marker to separate exosomes released by melanoma cells from exosomes released by nonmalignant cells. The results are discussed in view of the potential role of melanoma cell-derived exosomes in the escape of malignant cells from the host’s immune system.