Increased expression of Forkhead box M1 transcription factor is associated with clinicopathological features and confers a poor prognosis in human hepatocellular carcinoma

Egawa Mayumi; Yoshida Yuichi; Ogura Satoshi; Kurahashi Tomohide; Kizu Takashi; Furuta Kunimaro; Kamada Yoshihiro; Chatani Norihiro; Hamano Mina; Kiso Shinichi; Hikita Hayato; Tatsumi Tomohide; Eguchi Hidetoshi; Nagano Hiroaki; Doki Yuichiro; Mori Masaki; Takehara Tetsuo

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Increased expression of Forkhead box M1 transcription factor is associated with clinicopathological features and confers a poor prognosis in human hepatocellular carcinoma

机译：叉头箱M1转录因子的表达增加与临床病理特征有关，并赋予人类肝细胞癌的预后差

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Aim: Forkhead Box M1 (FoxM1) is a proliferation-specific transcription factor. In this study, we aimed to elucidate the clinicopathological and prognostic values of FoxM1 expression in human hepatocellular carcinoma (HCC) and correlate FoxM1 expression with various etiologies of liver diseases. We also investigated its therapeutic value in HCC.

机译：目的：FORKHEAD盒M1（FOXM1）是一种细胞增殖的转录因子。在这项研究中，我们旨在阐明人肝细胞癌（HCC）中FoxM1表达的临床病理和预后值，并与肝病的各种病因相关联Foxm1表达。我们还调查了HCC的治疗价值。

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来源
《Hepatology research: the official journal of the Japan Society of Hepatology》 |2017年第11期|共10页
作者
Egawa Mayumi; Yoshida Yuichi; Ogura Satoshi; Kurahashi Tomohide; Kizu Takashi; Furuta Kunimaro; Kamada Yoshihiro; Chatani Norihiro; Hamano Mina; Kiso Shinichi; Hikita Hayato; Tatsumi Tomohide; Eguchi Hidetoshi; Nagano Hiroaki; Doki Yuichiro; Mori Masaki; Takehara Tetsuo;
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作者单位

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol Surg Osaka Japan;

Yamaguchi Univ Grad Sch Med Dept Digest Surg &

Surg Oncol Yamaguchi Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol Surg Osaka Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol Surg Osaka Japan;

Osaka Univ Grad Sch Med Dept Gastroenterol &

Hepatol 2-2 Yamadaoka Suita Osaka 5650871 Japan;

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正文语种 eng
中图分类消化系及腹部疾病;
关键词
Forkhead box M1 transcription factor; hepatocellular carcinoma; prognostic biomarker; siomycin A;

机译：Forkhead盒M1转录因子;肝细胞癌;预后生物标志物;Siomycin A;

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专利

1. Increased expression of Forkhead box M1 transcription factor is associated with clinicopathological features and confers a poor prognosis in human hepatocellular carcinoma [J] . Egawa Mayumi, Yoshida Yuichi, Ogura Satoshi, Hepatology research: the official journal of the Japan Society of Hepatology . 2017,第11期

机译：叉头箱M1转录因子的表达增加与临床病理特征有关，并赋予人类肝细胞癌的预后差
2. Overexpression of Forkhead Box M1 transcription factor and nuclear factor-kappaB in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis. [J] . Jiang LZ, Wang P, Deng B, Human Pathology . 2011,第8期

机译：喉鳞状细胞癌中Forkhead Box M1转录因子和核因子-kappaB的过表达：预后不良的潜在指标。
3. Nuclear accumulation of glioma-associated oncogene 2 protein and enhanced expression of forkhead-box transcription factor M1 protein in human hepatocellular carcinoma. [J] . Lin M, Guo LM, Liu H, Histology and histopathology . 2010,第10a12期

机译：胶质瘤相关癌基因2蛋白的核积累和人类肝细胞癌中叉头盒转录因子M1蛋白的增强表达。
4. ACTIVATING TRANSCRIPTION FACTOR 4 INCREASE CHEMORESISTANCE OF HUMAN HEPATOCELLULAR CARCINOMA [C] . Zhuhong Zhang, Na Li, Dan Lv, 2011 Asia-Pacific Conference of tumor biology and medicine . 2011

机译：激活转录因子4提高人肝细胞癌的化学耐药性
5. The cell cycle-dependent regulation of Forkhead box M1 transcriptional activity by phosphorylation. [D] . Chen, Yi-Ju. 2009

机译：通过磷酸化对叉头盒M1转录活性的细胞周期依赖性调节。
6. Increased Expression of Forkhead Box M1 Is Associated with Aggressive Phenotype and Poor Prognosis in Estrogen Receptor-Positive Breast Cancer [O] . Hyein Ahn, Jongmin Sim, Rehman Abdul, 2015

机译：前叉箱M1表达增加与积极的表型和雌激素受体阳性乳腺癌的不良预后相关。
7. Altered Expression of the Transcription Factor Forkhead Box A1 (FOXA1) Is Associated With Poor Prognosis in Urothelial Carcinoma of the Upper Urinary Tract [O] . Raman, Jay D., Warrick, Joshua I., Caruso, Carla, 2016

机译：转录因子叉头盒A1（FOXA1）的表达改变与上尿路尿路上皮癌的预后不良相关。

Increased expression of Forkhead box M1 transcription factor is associated with clinicopathological features and confers a poor prognosis in human hepatocellular carcinoma

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