Randomized trial of combined triple therapy comprising two types of peginterferon with simeprevir in patients with hepatitis C virus genotype 1b

Tamori Akihiro; Yoshida Kanako; Kurai Osamu; Kioka Kiyohide; Hai Hoang; Kozuka Ritsuzo; Motoyama Hiroyuki; Kawamura Etsushi; Hagihara Atsushi; Uchida-Kobayashi Sawako; Morikawa Hiroyasu; Enomoto Masaru; Murakami Yoshiki; Kawada Norifumi

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Randomized trial of combined triple therapy comprising two types of peginterferon with simeprevir in patients with hepatitis C virus genotype 1b

机译：组合三重治疗组合试验，所述三重治疗包括两种Peginterferon与Simeprevir患者乙型肝炎病毒基因型1B

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摘要

Simeprevir (SMV) is a potent, macrocyclic hepatitis C virus (HCV) non-structural 3/4 A protease inhibitor. This prospective study compared the efficacy and safety of SMV in combination with peginterferon alpha 2a + ribavirin (P2aR) and with peginterferon alpha 2b + ribavirin (P2bR) in Japanese patients with HCV genotype 1b infection.

机译：Simeprevir（SMV）是一种有效的宏观环丙型肝炎病毒（HCV）非结构3/4 A蛋白酶抑制剂。该前瞻性研究将SMV与Peginterferonα2A+利巴韦林（P2AR）组合的疗效和安全性与日本HCV基因型1B感染的日本患者中的Peginterferonα2B+利巴韦林（P2BR）相结合。

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来源
《Hepatology research: the official journal of the Japan Society of Hepatology》 |2016年第13期|共10页
作者
Tamori Akihiro; Yoshida Kanako; Kurai Osamu; Kioka Kiyohide; Hai Hoang; Kozuka Ritsuzo; Motoyama Hiroyuki; Kawamura Etsushi; Hagihara Atsushi; Uchida-Kobayashi Sawako; Morikawa Hiroyasu; Enomoto Masaru; Murakami Yoshiki; Kawada Norifumi;
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作者单位

Osaka City Univ Grad Sch Med Dept Hepatol Osaka Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Osaka Japan;

Osaka City Juso Hosp Dept Gastroenterol Osaka Japan;

Osaka City Gen Hosp Dept Hepatol Osaka Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Osaka Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Osaka Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Osaka Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Osaka Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Osaka Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Osaka Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Osaka Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Osaka Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Osaka Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Osaka Japan;

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
hepatitis C virus; peginterferon alpha 2a; peginterferon alpha 2b; ribavirin; sustained virologic response;

机译：丙型肝炎病毒;Peginterferonα2a;Peginterferonα2b;利巴韦林;持续的病毒学反应;

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专利

1. Randomized trial of combined triple therapy comprising two types of peginterferon with simeprevir in patients with hepatitis C virus genotype 1b [J] . Tamori Akihiro, Yoshida Kanako, Kurai Osamu, Hepatology research: the official journal of the Japan Society of Hepatology . 2016,第13期

机译：丙型干扰素联合西美普韦两种类型的三联疗法在丙型肝炎病毒基因型1b患者中的随机试验
2. Simeprevir-Based Triple Therapy with Reduced Doses of Pegylated Interferon α-2a Plus Ribavirin for Interferon Ineligible Patients with Genotype 1b Hepatitis C Virus [J] . Hideyuki Tamai, Yoshiyuki Ida, Akira Kawashima, Gut and Liver . 2017,第4期

机译：基于Simeprevir的三联疗法，降低剂量的聚乙二醇化干扰素α-2a加利巴韦林对不适合干扰素的1b型丙型肝炎病毒患者的治疗
3. Comparative effectiveness and safety study of triple therapy with simeprevir or telaprevir for non-cirrhotic patients with chronic hepatitis C virus genotype 1b infection [J] . Ogawa Eiichi, Furusyo Norihiro, Kajiwara Eiji, Journal of gastroenterology and hepatology . 2015,第12期

机译：simeprevir或telaprevir三联疗法对慢性乙型肝炎病毒基因型1b感染的非肝硬化患者的比较有效性和安全性研究
4. Genotype and Serotype Identification of Hepatitis B Virus in Chronic Hepatitis B Patients Treated with Telbivudine [C] . Y Purnamasari, Tien, Arimaswati, International Seminar on Smart Molecule of Natural Resources . 2020

机译：临床治疗慢性乙型肝炎患者乙型肝炎病毒的基因型和血清型鉴定
5. Preclinical development of a prophylactic genotype 1a/1b consensus hepatitis C virus DNA vaccine. [D] . Latimer, Brian Paul. 2014

机译：预防性基因型1a / 1b共识性丙型肝炎病毒DNA疫苗的临床前开发。
6. Simeprevir-Based Triple Therapy with Reduced Doses of Pegylated Interferon α-2a Plus Ribavirin for Interferon Ineligible Patients with Genotype 1b Hepatitis C Virus [O] . Hideyuki Tamai, Yoshiyuki Ida, Akira Kawashima, 2017

机译：基于Simeprevir的三联疗法降低剂量的聚乙二醇化干扰素α-2a加利巴韦林对不适合干扰素的1b型丙型肝炎病毒患者的治疗
7. Randomized trial of combined triple therapy comprising two types of peginterferon with simeprevir in patients with hepatitis C virus genotype 1b [O] . Akihiro Tamori, Kanako Yoshida, Osamu Kurai, 2016

机译：丙型肝炎病毒基因型1B患者用Simeprevir包含两种Peginterferon的组合三重治疗组合三重治疗的随机试验

Randomized trial of combined triple therapy comprising two types of peginterferon with simeprevir in patients with hepatitis C virus genotype 1b

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