Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations

Avery Christy L.; Wassel Christina L.; Richard Melissa A.; Highland Heather M.; Bien Stephanie; Zubair Niha; Soliman Elsayed Z.; Fornage Myriam; Bielinski Suzette J.; Tao Ran; Seyerle Amanda A.; Shah Sanjiv J.; Lloyd-Jones Donald M.; Buyske Steven; Rotter Jerome I.; Post Wendy S.; Rich Stephen S.; Hindorff Lucia A.; Jeff Janina M.; Shohet Ralph V.; Sotoodehnia Nona; Lin Dan Yu; Whitsel Eric A.; Peters Ulrike; Haiman Christopher A.; Crawford Dana C.; Kooperberg Charles; North Kari E.

首页> 外文期刊>Heart rhythm: the official journal of the Heart Rhythm Society >Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations

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Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations

机译：全球群体中的Qt间隔区域的精细映射改进了先前识别的QT间隔基因座，并识别非洲和西班牙裔后期血统唯一的信号

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BACKGROUND The electrocardiographically measured QT interval (QT) is heritable and its prolongation is an established risk factor for several cardiovascular diseases. Yet, most QT genetic studies have been performed in European ancestral populations, possibly reducing their global relevance.

机译：背景技术心电图测量的QT间隔（QT）是遗传性的，其延长是几种心血管疾病的既定危险因素。然而，大多数Qt遗传研究已经在欧洲祖先群体中进行，可能降低了他们的全球相关性。

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《Heart rhythm: the official journal of the Heart Rhythm Society》 |2017年第4期|共9页
作者
Avery Christy L.; Wassel Christina L.; Richard Melissa A.; Highland Heather M.; Bien Stephanie; Zubair Niha; Soliman Elsayed Z.; Fornage Myriam; Bielinski Suzette J.; Tao Ran; Seyerle Amanda A.; Shah Sanjiv J.; Lloyd-Jones Donald M.; Buyske Steven; Rotter Jerome I.; Post Wendy S.; Rich Stephen S.; Hindorff Lucia A.; Jeff Janina M.; Shohet Ralph V.; Sotoodehnia Nona; Lin Dan Yu; Whitsel Eric A.; Peters Ulrike; Haiman Christopher A.; Crawford Dana C.; Kooperberg Charles; North Kari E.;
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作者单位

Univ North Carolina Chapel Hill Dept Epidemiol 137 E Franklin St Suite 306 Chapel Hill NC 27514;

Univ Vermont Coll Med Dept Pathol &

Lab Med Burlington VT USA;

Univ Texas Hlth Sci Ctr Houston Inst Mol Med Houston TX 77030 USA;

Univ North Carolina Chapel Hill Dept Epidemiol 137 E Franklin St Suite 306 Chapel Hill NC 27514;

Fred Hutchinson Canc Res Ctr Div Publ Hlth Sci 1124 Columbia St Seattle WA 98104 USA;

Fred Hutchinson Canc Res Ctr Div Publ Hlth Sci 1124 Columbia St Seattle WA 98104 USA;

Wake Forest Sch Med Epidemiol Cardiol Res Ctr Dept Epidemiol &

Prevent Winston Salem NC USA;

Univ Texas Hlth Sci Ctr Houston Inst Mol Med Houston TX 77030 USA;

Mayo Clin Dept Hlth Sci Res Div Epidemiol Rochester MN USA;

Univ North Carolina Chapel Hill Dept Biostat 137 E Franklin St Suite 306 Chapel Hill NC 27514;

Univ North Carolina Chapel Hill Dept Epidemiol 137 E Franklin St Suite 306 Chapel Hill NC 27514;

Northwestern Univ Feinberg Sch Med Dept Prevent Med Evanston IL 60208 USA;

Northwestern Univ Feinberg Sch Med Dept Prevent Med Evanston IL 60208 USA;

Rutgers State Univ Dept Stat &

Biostat Piscataway NJ USA;

Harbor UCLA Med Ctr Los Angeles Biomed Res Inst Inst Translat Genom &

Populat Sci Torrance CA;

Johns Hopkins Univ Dept Med Baltimore MD USA;

Univ Virginia Ctr Publ Hlth Genom Charlottesville VA USA;

NHGRI NIH Off Populat Genom Bethesda MD 20892 USA;

Icahn Sch Med Mt Sinai Genet &

Genom Sci Charles Bronfman Inst Personalized Med Ctr Stat Genet;

Univ Hawaii John A Burns Sch Med Ctr Cardiovasc Res Honolulu HI 96822 USA;

Univ Washington Div Cardiol Cardiovasc Hlth Res Unit Seattle WA 98195 USA;

Univ North Carolina Chapel Hill Dept Biostat 137 E Franklin St Suite 306 Chapel Hill NC 27514;

Univ North Carolina Chapel Hill Dept Epidemiol 137 E Franklin St Suite 306 Chapel Hill NC 27514;

Fred Hutchinson Canc Res Ctr Div Publ Hlth Sci 1124 Columbia St Seattle WA 98104 USA;

Univ Southern Calif Keck Sch Med Dept Prevent Med Pasadena CA USA;

Case Western Reserve Univ Dept Epidemiol &

Biostat Inst Computat Biol Cleveland OH 44106 USA;

Fred Hutchinson Canc Res Ctr Div Publ Hlth Sci 1124 Columbia St Seattle WA 98104 USA;

Univ North Carolina Chapel Hill Dept Epidemiol 137 E Franklin St Suite 306 Chapel Hill NC 27514;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Hispanic/Latino; African American; QT interval; Fine mapping; Electrocardiography;

机译：西班牙裔/拉丁裔;非洲裔美国人;Qt间隔;精细映射;心电图;

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外文文献
专利

1. Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations [J] . Avery Christy L., Wassel Christina L., Richard Melissa A., Heart rhythm: the official journal of the Heart Rhythm Society . 2017,第4期

机译：全球群体中的Qt间隔区域的精细映射改进了先前识别的QT间隔基因座，并识别非洲和西班牙裔后期血统唯一的信号
2. GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals [J] . Raúl Méndez-Giráldez, Stephanie M. Gogarten, Jennifer E. Below, Scientific reports. . 2017,第1期

机译：西班牙裔/拉丁裔心电图QT间隔的GWAS概括了先前确定的基因座并确定了特定于人群的信号
3. Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci [J] . NihaZubair, MariaelisaGraff, JoseLuis Ambite, Human Molecular Genetics . 2016,第24期

机译：全球群体中的脂质区的精细映射发现了种类特定的信号，并改善先前识别的脂质基因座
4. Large Population with Low Marker Density Verse Small Population with High Marker Density for QTL Mapping: A Case Study for Mapping QTL Controlling Barley Net Blotch Resistance [C] . Jian Yang, Chengdao Li, Xue Gong, Advance in barley sciences : proceedings of 11th international barley genetics symposium . 2012

机译：低标记密度的大种群与QTL映射的高标记密度的小种群：以控制大麦净抗斑点性的QTL作图的案例研究
5. Mapping cold tolerance quantitative trait loci (QTL) in a Citrus grandis x Poncirus trifoliata F(1) pseudo-testcross population using molecular markers and evaluation of homology with a related population map. [D] . Weber, Courtney Alyn. 1999

机译：映射耐寒定量性状基因座（QTL）在柑橘x三角叶F（1）伪testcross人口使用分子标记和与相关人口图的同源性评估。
6. Fine-Mapping of QT Regions in Global Populations Refines Previously Identified QT Loci and Identifies Signals Unique to African and Hispanic Descent Populations [O] . Christy L. Avery, Christina L. Wassel, Melissa A. Richard, -1

机译：全球人口中QT区域的精细映射完善了先前确定的QT基因座并鉴定了非洲和西班牙裔血统人口的独特信号
7. Q-T-Interval in Relatie tot Totale, Cardiovasculaire en IschaemischeHartziektesterfte: Een Prospektieve Studie onder Amsterdamse Ambtenaren (QT-Interval Prolongation Predicts Cardiovascular Mortality in the General Population) [R] . Meppelink, P. 1990

机译：Q-T-Interval in Relatie tot Totale，Cardiovasculaire en IschaemischeHartziektesterfte：Een prospektieve studie onder amsterdamse ambtenaren（QT-Interval延长预测一般人群中的心血管死亡率）

Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations

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