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首页> 外文期刊>Helicobacter >Probiotic supplementation with Lactobacillus plantarum and Pediococcus acidilactici for Helicobacter pyloriHelicobacter pylori therapy: A randomized, double‐blind, placebo‐controlled trial
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Probiotic supplementation with Lactobacillus plantarum and Pediococcus acidilactici for Helicobacter pyloriHelicobacter pylori therapy: A randomized, double‐blind, placebo‐controlled trial

机译：益生菌补充乳酸杆菌和Pediococcus acidilactici用于幽门螺杆菌幽门螺杆菌幽门螺杆菌治疗：随机，双盲，安慰剂对照试验

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Abstract <section numbered="no" xml:id="hel12529-sec-0001"> <title type="main">Objective > To evaluate the safety, tolerability and efficacy of a probiotic supplementation for Helicobacter pylori (H.?pylori) eradication therapy. </section> <section numbered="no" xml:id="hel12529-sec-0002"> <title type="main">Design > Consecutive adult naive patients with a diagnosis of H.?pylori infection who were prescribed eradication therapy according to clinical practice (10‐day triple or nonbismuth quadruple concomitant therapy) randomly received probiotics (1?×?10 9 colony‐forming units each strain, Lactobacillus plantarum and Pediococcus acidilactici ) or matching placebo. Side effects at the end of the treatment, measured through a modified De Boer Scale, were the primary outcome. Secondary outcomes were compliance with therapy and eradication rates. </section> <section numbered="no" xml:id="hel12529-sec-0003"> <title type="main">Results > A total of 209 patients (33% triple therapy, 66% non‐bismuth quadruple therapy) were included [placebo (n?=?106) or probiotic (n?=?103)]. No differences were observed regarding side effects at the end of the treatment between groups (β ?0.023, P 0.738). Female gender ( P ?<?0.001) and quadruple therapy ( P 0.007) were independent predictors of side effects. No differences in compliance were observed, regardless of the study group or eradication therapy. Eradication rates were similar between groups [placebo 95% (95 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“Hel12529-Abs-Abs-0001”> <标题类型=“main”>抽象</ title> <secto numbyed =“no”xml：id =“hel12529-sec-0001” > <标题类型=“main”>目标</标题> >，评估益生菌补充剂的安全性，耐受性和疗效，对幽门螺杆菌（H.?丙棒）</ i>根除治疗。 </ p> </ section> <secto numbyed =“no”xml：id =“hel12529-sec-0002”> <标题类型=“main”> design </ title> >连续成年人天真< / i>诊断为诊断 h.?普罗尼的感染者，其被规定的临床实践（10天三元或非双产伴随治疗）随机接受益生菌（1？×10 < sup> 9 </ sup>菌落形成单元每种菌株，乳酸杆菌植物和 pediococcus acidilactici或匹配的安慰剂。通过改进的德波尔规模测量的治疗结束时的副作用是主要的结果。二次结果与治疗和根除率符合符合性。 </ p> </部分> <部分编号=“否”XML：ID =“Hel12529-SEC-0003”> <标题类型=“main”>结果</标题> >共209名患者（33包括三重疗法，66％非铋四重治疗）[安慰剂（n？=α106）或益生菌（n？=α103）]。在组之间处理结束时没有观察到副作用的副作用（β？0.023， P </ I> 0.738）。女性性别（ p </ i>？<？0.001）和四重治疗（ p </ i> 0.007）是副作用的独立预测因子。无论研究组还是根除治疗如何，都没有观察到合规性差异。群体之间的根除率相似[安慰剂95％（95 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32409/'>《Helicobacter》</a> <b style="margin: 0 2px;">|</b><span>2018年第5期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=McNicholl Adrian G.&option=202" target="_blank" rel="nofollow">McNicholl Adrian G.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Molina‐Infante Javier&option=202" target="_blank" rel="nofollow">Molina‐Infante Javier;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lucendo Alfredo J.&option=202" target="_blank" rel="nofollow">Lucendo Alfredo J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Calleja José Luis&option=202" target="_blank" rel="nofollow">Calleja José Luis;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pérez‐Aisa ángeles&option=202" target="_blank" rel="nofollow">Pérez‐Aisa ángeles;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Modolell Inés&option=202" target="_blank" rel="nofollow">Modolell Inés;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Aldeguer Xavier&option=202" target="_blank" rel="nofollow">Aldeguer Xavier;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Calafat Margalida&option=202" target="_blank" rel="nofollow">Calafat Margalida;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Comino Luis&option=202" target="_blank" rel="nofollow">Comino Luis;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ramas Mercedes&option=202" target="_blank" rel="nofollow">Ramas Mercedes;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Callejo ángel&option=202" target="_blank" rel="nofollow">Callejo ángel;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Badiola Carlos&option=202" target="_blank" rel="nofollow">Badiola Carlos;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Serra Jordi&option=202" target="_blank" rel="nofollow">Serra Jordi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gisbert Javier P.&option=202" target="_blank" rel="nofollow">Gisbert Javier P.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa (IIS‐IP) and Universidad Autónoma de MadridMadrid Spain;</p> <p>Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)Madrid Spain;</p> <p>Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)Madrid Spain;</p> <p>Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)Madrid Spain;</p> <p>Agencia Sanitaria Costa del SolMarbella Spain;</p> <p>Centre Mèdic MolletBarcelona Spain;</p> <p>Hospital Universitari Dr. Josep TruetaGirona Spain;</p> <p>Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)Madrid Spain;</p> <p>CAP Sant Pere i Sant PauTarragona Spain;</p> <p>Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa (IIS‐IP) and Universidad Autónoma de MadridMadrid Spain;</p> <p>Apices Soluciones S.L.Madrid Spain;</p> <p>Casen Recordati S.L.Madrid Spain;</p> <p>Hospital Universitari Germans Trias i PujolBadalona Spain;</p> <p>Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa (IIS‐IP) and Universidad Autónoma de MadridMadrid Spain;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=H.?pylori&option=203" rel="nofollow">H.?pylori;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lactobacillus plantarum&option=203" rel="nofollow">Lactobacillus plantarum;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pediococcus acidilactici&option=203" rel="nofollow">Pediococcus acidilactici;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=probiotics&option=203" rel="nofollow">probiotics;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=randomized clinical trial&option=203" rel="nofollow">randomized clinical trial;</a> </p> <div class="translation"> 机译：H.?吡咯;羊驼属植物;pediococcus acidilactici;益生菌;随机临床试验; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div 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Myllyluoma&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">E. Myllyluoma,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=L. Veijola&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">L. Veijola,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=T. Ahlroos&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">T. Ahlroos,</a> <span>2005</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：益生菌补充改善了幽门螺杆菌根除治疗的耐受性 - 一种安慰剂控制的双盲随机试验研究</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_world-latest-medicine-information_thesis/0201275216037.html">幽门螺杆菌根除治疗对高感染率人群中无溃疡性消化不良患者的临床结果：一项为期12个月的随机、双盲、安慰剂对照研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mazzoleni&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Mazzoleni</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=L&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,L</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=E.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,E.</a> <span> <a href="/journal-cn-6057/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界核心医学期刊文摘：胃肠病学分册 </a> </span> <span> . 2006</span><span>,第006期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_world-latest-medicine-information_thesis/0201285798042.html">乳酸杆菌GG作为泻药乳果糖附加物治疗儿童便秘是无效的:一双盲、安慰剂对照随机试验</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Banaszkiewicz A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Banaszkiewicz A.</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Szajewska H.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Szajewska H.</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=贺莉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,贺莉</a> <span> <a href="/journal-cn-6198/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界核心医学期刊文摘：儿科学分册 </a> </span> <span> . 2005</span><span>,第008期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_world-core-medical-journal-abstracts-pediatrics_thesis/0201267871265.html">规律摄取酵母益生菌添加菊粉或嗜酸性乳酸杆菌LB对于幽门螺杆菌感染患儿的治疗作用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gotteland&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Gotteland</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=M.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,M.</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Poliak&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Poliak</a> <span> <a href="/journal-cn-52170/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界核心医学期刊文摘：儿科学分册 </a> </span> <span> . 2006</span><span>,第006期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-immunology_thesis/0201223348987.html">含幽门螺杆菌特异性抗体牛奶清除幽门螺杆菌效果的临床随机试验</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵连梅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 赵连梅</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=魏思思&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,魏思思</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=武一鹏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,武一鹏</a> <span> <a href="/journal-cn-5793/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国免疫学杂志 </a> </span> <span> . 2017</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-general-practice_thesis/0201255971730.html">荆花胃康三联疗法治疗幽门螺杆菌阳性慢性胃炎临床疗效的多中心随机双盲临床研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=韩玉山&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 韩玉山</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨强&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨强</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王东旭&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王东旭</a> <span> <a href="/journal-cn-16641/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国全科医学 </a> </span> <span> . 2011</span><span>,第031期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-11108_thesis/02022284378.html">荆花胃康胶丸三联疗法治疗幽门螺杆菌阳性慢性胃炎的多中心随机双盲临床研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=韩玉山&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 韩玉山</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=文君&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,文君</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨强&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨强</a> <span> <a href="/conference-cn-11108/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第二十三届全国中西医结合消化系统疾病学术会议 </a> <span> <span> . 2011</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020315263666.html">幽门螺杆菌感染，根除治疗和益生菌补充对肠道微生物群的影响</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄碧霞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 黄碧霞</a> <span> . 2018</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120112908630.html">抗幽门螺杆菌、降血糖、调理肠胃和增加免疫力的复合乳酸杆菌制剂及其制备方法</a> <b>[P]</b> . <span> 中国专利： CN112940984A </span> <span> . 2021-06-11</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120100374395.html">一种用于抑制幽门螺杆菌活性的益生菌组合物及其应用</a> <b>[P]</b> . <span> 中国专利： CN109645489A </span> <span> . 2019-04-19</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130420365284.html">Composition comprising Lactobacillus plantarum and Pediococcus acidilactici or Mutant or variants thereof, Pharmaceutical Product, Veterinary and Food comprising Said composition; Lactobacillus plantarum Strain; Strain of Pediococcus acidilactici.</a> <b>[P]</b> . <span> 外国专利： <!-- --> CL2012002062A1 </span> <span> . 2013-10-04</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含植物乳杆菌和嗜酸乳球菌或其突变体或变体的组合物，包含所述组合物的药物，兽医和食品;植物乳杆菌菌株;嗜酸小球菌菌株。 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130441593273.html">BACTERIOCIN OF LACTOBACILLUS PLANTARUM ISOLATED FROM KIMCHI WHICH HAS INHIBITING EFFECT ON HELICOBACTER PYLORI</a> <b>[P]</b> . <span> 外国专利： <!-- 韩国专利： --> KR20040092276A </span> <span> . 2004-11-03</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：朝鲜泡菜中分离出的乳酸菌对幽门螺杆菌有抑制作用 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130441565681.html">LACTOBACILLUS PLANTARUM ISOLATED FROM KIMCHI WITH INHIBITING ACTIVITIES ON HELICOBACTER PYLORI</a> <b>[P]</b> . <span> 外国专利： <!-- 韩国专利： --> KR100435505B1 </span> <span> . 2004-06-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：朝鲜泡菜中分离出的乳酸菌对幽门螺杆菌具有抑制活性 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" 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