Efficacy of three‐in‐one capsule bismuth quadruple therapy for        <i >Helicobacter pyloriHelicobacter pylori        eradication in clinical practice in a multinational patient population

Miehlke Stephan; Frederking Dorothea; Günther Thomas; Glocker Erik; Eisele Bianca; Andresen Viola; Schr?der S?ren; Morgner Andrea

摘要

Abstract <section numbered="no" xml:id="hel12429-sec-0001"> <title type="main">Background > Bismuth quadruple therapy ( <fc>BQT</fc> ) has been proven superior to standard triple therapy for Helicobacter pylori eradication in randomized clinical trials; however, little is known about the efficacy of <fc>BQT</fc> in daily routine practice. </section> <section numbered="no" xml:id="hel12429-sec-0002"> <title type="main">Methods > In a single‐center cohort study, we analyzed consecutive H.?pylori ‐positive patients in whom three‐in‐one capsule <fc>BQT</fc> (Pylera ? + omeprazole) has been prescribed. All patients were instructed in a standardized fashion, and a prospective follow‐up was planned. <fc>PCR</fc> on gastric biospies for clarithromycin and levofloxacin resistance was performed before treatment in a subgroup of patients. Treatment outcome was assessed by 13C urea breath test or by histology not earlier than 4?weeks after end of treatment. </section> <section numbered="no" xml:id="hel12429-sec-0003"> <title type="main">Results > Three‐in‐one capsule <fc>BQT</fc> has been prescribed in 322 patients. Approximately 70.2% of patients had a migrational background. <fc>PCR</fc> results were available in 163 patients and identified resistance to clarithromycin and levofloxacin in 29 (17.8%) and 20 (12.3%) of cases, respectively. <fc>BQT</fc> was prescribed as first‐line, second‐line, and salvage treatments in 74%, 17%, and 9% of cases, respectively. Five pat </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“Hel12429-Abs-Abs-0001”> <标题类型=“main”>抽象</ title> <secueeded =“no”xml：id =“hel12429-sec-0001” > <标题类型=“main”>背景</ title> > Biscuth四重治疗（<fc> bqt </ fc>）已被证明优于标准三重治疗幽门螺杆菌</ i>根除随机临床试验;然而，关于每日常规实践中<FC> BQT </ FC>的功效很少。 </ p> </ section> <secto numbyed =“no”xml：id =“hel12429-sec-0002”> <标题类型=“main”>方法</ title> >在单中心队列研究中，我们分析了连续的 H.?吡喃酮（Theworive患者），其中三合一胶囊<Fc> BQT </ Fc>（Pylera <Sup>α</ sup> +奥美拉唑）已经规定。所有患者均以标准化的方式指示，并计划前瞻性随访。在患者亚组的治疗前进行Clarromycin和左旋氧化嘧啶抗性的胃生物分子上的<FC> PCR </ FC>。通过13C尿素呼气试验或通过组织学不早于4？治疗结束后的组织学评估治疗结果。 </ p> </段> <部分编号=“否”XML：ID =“Hel12429-SEC-0003”> <标题类型=“main”>结果</ title> >三合一胶囊< FC> BQT </ FC>已在322名患者中规定。大约70.2％的患者有迁徙的背景。 <FC> PCR </ Fc>在163名患者中提供了结果，并分别鉴定了29例（17.8％）和20例（12.3％）的含量的含量霉素和左氧氟沙星。 <FC> BQT </ FC>分别以74％，17％和9％的病例分别为一线，二线和挽救物处理。五拍 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32409/'>《Helicobacter》</a> <b style="margin: 0 2px;">|</b><span>2017年第6期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Miehlke Stephan&option=202" target="_blank" rel="nofollow">Miehlke Stephan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Frederking Dorothea&option=202" target="_blank" rel="nofollow">Frederking Dorothea;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Günther Thomas&option=202" target="_blank" rel="nofollow">Günther Thomas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Glocker Erik&option=202" target="_blank" rel="nofollow">Glocker Erik;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Eisele Bianca&option=202" target="_blank" rel="nofollow">Eisele Bianca;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Andresen Viola&option=202" target="_blank" rel="nofollow">Andresen Viola;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schr?der S?ren&option=202" target="_blank" rel="nofollow">Schr?der S?ren;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Morgner Andrea&option=202" target="_blank" rel="nofollow">Morgner Andrea;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Center of Digestive DiseasesInternal Medicine Center EppendorfHamburg Germany;</p> <p>Center of Digestive DiseasesInternal Medicine Center EppendorfHamburg Germany;</p> <p>Institute of Pathology LademannbogenHamburg Germany;</p> <p>Institute of Laboratory MedicineBrandenburg HospitalBrandenburg Germany;</p> <p>Department of Medical Microbiology and HygieneUniversity Hospital FreiburgFreiburg Germany;</p> <p>Department of MedicineIsraelitic HospitalHamburg Germany;</p> <p>Institute of Pathology LademannbogenHamburg Germany;</p> <p>University Cancer Center University HospitalHamburg Germany;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=bismuth quadruple therapy&option=203" rel="nofollow">bismuth quadruple therapy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=clarithromycin resistance&option=203" rel="nofollow">clarithromycin resistance;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=eradication therapy&option=203" rel="nofollow">eradication therapy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Helicobacter pylori&option=203" rel="nofollow">Helicobacter pylori;</a> </p> <div class="translation"> 机译：铋四重疗法;克拉霉素抵抗;根除疗法;幽门螺杆菌; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025098801.html">Efficacy of three‐in‐one capsule bismuth quadruple therapy for <i >Helicobacter pyloriHelicobacter pylori eradication in clinical practice in a multinational patient population</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Miehlke Stephan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Miehlke Stephan,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Frederking Dorothea&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Frederking Dorothea,</a> <a 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</div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-6068_thesis/020221592357.html">多中心临床观察荆花胃康联合三联疗法治疗幽门螺杆菌感染慢性胃炎疗效分析</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张月苗&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张月苗</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张学智&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张学智</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=成虹&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,成虹</a> <span> <a href="/conference-cn-6068/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界中医药学会联合会消化病专业委员会第四届消化病国际学术大会 </a> <span> <span> . 2013</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313590656.html">序贯疗法与传统三联疗法治疗幽门螺杆菌感染的消化性溃疡的临床疗效观察</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李清琛&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 李清琛</a> <span> . 2014</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120100730113.html">一种杀灭幽门螺杆菌治疗胃溃疡的沙棘原花青素软胶囊及制法</a> <b>[P]</b> . <span> 中国专利： CN109954008A </span> <span> . 2019-07-02</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120102921020.html">一种治疗消化性溃疡及抗幽门螺杆菌的胶囊</a> <b>[P]</b> . <span> 中国专利： CN104352939A </span> <span> . 2015-02-18</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130444570576.html">A double-layered capsule with a soluble bismuth salt and an antibiotic in the external capsule and a second antibiotic and a potassium/sodium ATPase inhibitor in the internal capsule for therapy against Helicobacter pylori</a> <b>[P]</b> . <span> 外国专利：  NZ505655A </span> <span> . 2003-09-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：双层胶囊，在外部胶囊中含有可溶性铋盐和抗生素，在内部胶囊中含有第二种抗生素和钾/钠ATP酶抑制剂，用于治疗幽门螺杆菌 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130418303476.html">HIGH EFFICACY COMBINATION THERAPY FOR HELICOBACTER PYLORI ERADICATION AND PACKAGING FOR THE DISTRIBUTION AND USE THEREOF</a> <b>[P]</b> . <span> 外国专利：  US2014323419A1 </span> <span> . 2014-10-30</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：幽门螺杆菌根除和包装的高效联合疗法及其使用 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130431750285.html">METHOD OF ERADICATION THERAPY SELECTION FOR ULCER PATIENTS ASSOCIATED WITH Helicobacter pylori</a> 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Efficacy of three‐in‐one capsule bismuth quadruple therapy for Helicobacter pyloriHelicobacter pylori eradication in clinical practice in a multinational patient population

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