High-throughput Cytological Discovery System

摘要

In the field of new drug discovery, the high content analysis (HCA) system is becoming popular for screening several hundred thousand compounds to identify promising candidates for new drugs. In HCA, cells are imaged with a microscopic-camera, and their temporal changes are analyzed. To observe biological changes in living cells and identify the effect of the candidate compounds, it is necessary to observe living cells for a long time. Also, there is an increasing need to eliminate the effect of fluorescent labeling in cells and observe cell behavior without labeling, although intracellular functional molecules and organelles are generally labeled with fluorescent dyes for HCA analysis. However, automatic image analysis of label-free cells is challenging because their image contrast is lower than that of labeled cells. The CellVoyager CV8000 satisfies these latest needs.