Changing Profile of Primary Hyperparathyroidism Over Two and Half Decades: A Study in Tertiary Referral Center of North India

摘要

Background Most of the cases of PHPT in developing countries present in symptomatic stage, some even in very advanced stage but in recent years the trend seems to be changing. This has been corroborated from few recently published literature from developing countries. The scope of this study is to further carry out an in-depth analysis of various clinical and biochemical parameters of PHPT patients at a tertiary care center of northern India. Methods In this retrospective analysis, a total of 333 patients with PHPT from the year 1990 to 2016 were studied. The study population was divided into three subgroups based on the time span; 1990–1999 ( n ?=?34), 2000–2009 ( n ?=?112), 2010–2016 ( n ?=?187), and clinical and biochemical parameters were compared. Results The clinical presentation has evolved progressively with increase in older age group (35 vs 39 vs 43.85, p ?