Explore the Copper-Catalyzed Asymmetric Conjugate Addition

摘要

The asymmetric conjugate addition reaction has been extensively studied for the past decade. This effort stems from the importance of this method for the formation of C-C bonds concomitant with the introduction of a chiral center. Mauduit and co-workers developed new chiral N-heterocyclic carbene ligands for this transformation. One of the examples highlighted in the review is the copper-catalyzed asymmetric conjugate addition of dialkyzincs to cyclic enones. Good yields and selectivities were reported.