首页> 外文期刊>Twin research and human genetics : >Understanding Mechanisms of Genetic Risk for Adolescent Internalizing and Externalizing Problems: The Mediating Role of Parenting and Personality
【24h】

Understanding Mechanisms of Genetic Risk for Adolescent Internalizing and Externalizing Problems: The Mediating Role of Parenting and Personality

机译:理解青少年内化和外化问题的遗传风险机制:养育和个性的中介作用

获取原文
获取原文并翻译 | 示例

摘要

Genetic predispositions play an important role in the development of internalizing and externalizing behaviors. Understanding the mechanisms through which genetic risk unfolds to influence these developmental outcomes is critical for developing prevention and intervention efforts, capturing key elements of Irv's research agenda and scientific legacy. In this study, we examined the role of parenting and personality in mediating the effect of genetic risk on adolescents’ major depressive disorder and conduct disorder symptoms. Longitudinal data were drawn from a sample of 709 European American adolescents and their mothers from the Collaborative Studies on Genetics of Alcoholism. Results from multivariate path analysis indicated that adolescents’ depressive symptoms genome-wide polygenic scores (DS_GPS) predicted lower parental knowledge, which in turn was associated with more subsequent major depressive disorder and conduct disorder symptoms. Adolescents’ DS_GPS also had indirect effects on these outcomes via personality, with a mediating effect via agreeableness but not via other dimensions of personality. Findings revealed that the pattern of associations was similar across adolescent gender. Our findings emphasize the important role of evocative gene–environment correlation processes and intermediate phenotypes in the pathways of risk from genetic predispositions to complex adolescent outcomes.
机译:遗传易感性在内化和外化行为的发展中起着重要作用。了解遗传风险展开影响这​​些发展成果的机制对于制定预防和干预努力至关重要,捕捉IRV的研究议程和科学遗产的关键要素。在这项研究中,我们研究了养育和个性在介导遗传风险对青少年的主要抑郁症的影响和进行疾病症状的作用。从709名欧洲美国青少年和母亲的样本中汲取纵向数据,从酗酒遗传学的协作研究中。多变量路径分析的结果表明青少年的抑郁症状基因组 - 宽的多基因分数(DS_GPS)预测较低的父母知识,这反过来与更随后的主要抑郁症和进行疾病症状相关。青少年的DS_GPS也通过个性对这些结果进行间接影响,通过协议,介导效果,但不通过其他人格的其他方面。调查结果表明,关联的模式在青少年性别中相似。我们的研究结果强调了兴奋性基因环境相关过程和中间表型在遗传易感性对复杂的青少年结果的风险途径中的重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号